European cities face a myriad of urban challenges ranging from the rise of digitalization to societal inequalities, climate change and environmental degradation. Supporting cities through an inclusive twin transition unites the members of U!REKA SHIFT (Urban Research and Education Knowledge Alliance for Sustainable, Human, Inclusive and Future proof Transition). We are six European Universities of Applied Sciences with 26 associated partners (cities, regions, associations and other universities). U!REKA SHIFT has three main objectives: 1. To establish a sustainable U!REKA inter-university campus, based on a long-term strategy on education, ensuring seamless mobility and with respect for good governance 2. To become a lighthouse European University for challenge-based and collaborative learning and innovation 3. To shape U!REKA future-proof urban professionals who will accelerate the transition towards Climate-Neutral and Smart Cities To accomplish our objectives, we will integrate each partner’s education and research resources to develop an inclusive and connected campus with 70 open courses on sustainability and digital transitions including a virtual, blended or physical mobility component. We will target 61.500 students (50%), 3.700 staff members (30%) and 2.000 lifelong learners to benefit from such education and training. We will also establish three interdisciplinary Centres of Expertise (CoE): 1) Climate-Neutral Urban Communities, 2) Transition to Circular Society, and 3) Innovative Governance Models & Citizen Engagement; to promote challenge-based and collaborative learning and innovation. In connection to our CoEs and the underlying needs of our society, we will develop 18 micro-credentials, two minors, three double degrees (BSc, MSc, PhD), a joint MSc. degree program, an internship program and an incubator program. This is how we aim to contribute to twin transition, strengthen European identity and the quality of European Higher Education.