E³UDRES² 2.0 promotes Smart and Sustainable Regions to shape a peaceful and prosperous European future for responsible citizens as a pioneering full-fledged Engaged and Entrepreneurial European University, unites 9higher education institutions and 37 associated partners across Europe and establishes enhanced partnerships with Western Balkans and Ukraine. A Multi-i-Culture (innovative, interdisciplinary, intercultural…) underpins excellence in challenge-based education, mission-oriented research, human-centred innovation and engaged knowledge exchange with stakeholders across the knowledge-square. E³UDRES² strives to enable Smart Learners to unfold talents, empowers ent-r-e-novators (entrepreneurs, researchers, educators, innovators) to accelerate future universities, serves as a platform for collaborative innovation to connect entrepreneurial minds, engages in regional communities to contribute to society and shifts to a fully-fledged European university to ensure excellent quality. E³UDRES² co-creates its Multi-i-Campus for flexible learning offering joint lectures, modules, internships, micro-credentials and (European) degrees, a talent funnel for smart learners, a joint support centre, doctoral schools and research centres of excellence, an entrepreneurship and innovation network for S²-Regions, interconnected (pre-)incubators fostering startups and entrepreneurial education, an ecosystem for regional partners and citizens, a proactively operating umbrella organisation as a legal entity and a future university model as an updated E³UDRES² strategy ensuring a fully-fledged European University sustainably implemented beyond 2030. E³UDRES² 2.0 measures progress with a set of 20 Core-KPIs and target values that include 50.000 benefitting students, 360 E³UDRES² labeled and 20 jointly developed learning activities, 50 associated startups/spin-offs, 200 solutions to regional challenges, 70 services for/with society and 450 submissions to E³UDRES² awards of excellence.