BIOMED5.0 aims to establish an international partnership between Pakistani, Irish, and Romanian higher education institutions (HEIs) to modernize and transform Biomedical Engineering (BME) education. BIOMED5.0 objective is to incorporate digital transformation enabling Industry 4.0/5.0 technologies in BME bachelor and master programmes aiming at increasing students’ understanding and knowledge in Industry 4.0/5.0 technologies and to upgrade teaching labs and introduce innovative Virtual Reality, Augmented Reality and Mixed Reality laboratory sessions for enhanced students learning experience. The project aims to foster collaboration between Knowledge Triangle players, promoting innovation and entrepreneurship. To achieve these goals, BIOMED5.0 will revise the Programme Educational Objectives and Learning Outcomes for the targeted modules via stakeholder inputs. The project will develop and implement 6 new bachelor and master modules and introduce elements of Industry 4.0/5.0 technologies in 12 existing modules. 5 new micro-credential Open Online Courses (OOC) on Industry 4.0/5.0 will be introduced for professionals as life-long learning. BIOMED5.0 will develop VR/AR/MR based lab training sessions for diagnostic and therapeutic BME devices. The centre will act as a technology incubation hub to drive innovation and support entrepreneurship in BME and healthcare through providing access to fabrication labs and mentorship programmes. BIOMED5.0 will benefit approximately 640 academic and 80 lab staff, over 10,000 BME bachelor and master students, 500 working/open to work professionals, and more than 80 entrepreneurs. BIOMED5.0 will build the capacity of partner HEIs through trainings in Industry 4.0/5.0 technologies, transformative skills, and mental well-being to academic and lab staff, students, and entrepreneurs. BIOMED5.0 will increase awareness and adoption of digital transformation and BIOMED5.0 outcomes through comprehensive dissemination & communication efforts.