HELIUM, as a 24-months initiative will transform HEIs by resolving key challenges of governance, internationalisation, digitalisation, diversification & employability. HELIUM is designed with the aim to bridge internationalization, modernize educational practices, and instil structured university-industry collaboration. HELIUM, as a chemical element, is light, elevating, and essential for high-altitude advancements, as metaphor for what to achieve in the realm of higher education. HELIUM lifts universities towards Internationalization, Inclusivity, and Digital Transformation. HELIUM operates through 3 Strategic Pillars, as a Triple Helix Model for Cross-Regional Reforming HEIs in Egypt (South Mediterranean) and Ukraine (Neighbourhood East), in accordance with their needs for: 1. Inclusion and Human Development in HEI; 2. Internationalized Reformation using Digital Means and; 3. Qualitative Modernized Industry Linkage: Governance & Internationalization (Pillar 1)–Establishing university policies and digital mobility mechanisms. Equity & Inclusion (Pillar 2)–Ensuring access for all learners and underrepresented HEIs, especially migrants and from displaced areas. Digital Learning & Industry Integration (Pillar 3)–Enhancing skills development, employability, and entrepreneurship. HELIUM Target Groups are Academic Staff, Administrative Staff, Women, Students, Migrants and those from displaced areas and civil society and NGOs. HELIUM 24-months Work Plan follows a logical sequence, ensuring the structured undertaking from Diagnostics and development of framework, Implementation of capacity-building and Institutionalization. HELIUM Model allows continuous collaboration among universities, industries and policymakers to make substantial differences. The digital ecosystem of HELIUM is an enabler for sustainability in modernisation, inclusivity, and internationalisation. HELIUM is expected to reach 2,893 gender-balanced participants, out of which 346 with fewer opportunities.