Respond to the demand of specialists caused by the introduction of disruptive technologies in medical device manufacturing under MDR Regulation (EU) 2017/745 by: O1: Incorporating Industry 4.0 (AR/VR, 3D Bioprinting, AI) in Biomedical Engineering curricula. O2: Adopting new digital teaching methods for transnational knowledge-exchange in the e-Metaverse. O3: Promoting personalized device manufacturing to encourage med-tech entrepreneurship. O4: Fostering collaboration across med-tech agents.